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Periactin is an antihistamine given to help relieve cold- and allergy-related symptoms such as hay fever, nasal inflammation, stuffy nose, red and inflamed eyes, hives, and swelling. Periactin may also be given after epinephrine to help treat anaphylaxis, a life-threatening allergic reaction.

Some doctors prescribe Periactin to treat cluster headache and to stimulate appetite in underweight people.
Most important fact about Periactin

Like other antihistamines, Periactin may make you feel sleepy and sluggish. However, some people, particularly children, may have the opposite reaction and become excited.
How should you take Periactin?

Take Periactin exactly as prescribed by your doctor.

* If you miss a dose…
Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at once.

* Storage instructions…
Store at room temperature in a tightly closed container.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor immediately. Only your doctor can determine whether it is safe for you to continue taking Periactin.

* Side effects may include:
Anaphylaxis (life-threatening allergic reaction), anemia, appetite loss, chest congestion or tightness, chills, confusion, constipation, convulsions, diarrhea, difficulty urinating, dizziness, dry mouth, nose, or throat, earlier-than-expected menstrual period, exaggerated feeling of well-being, excessive perspiration, excitement, faintness, fatigue, fluttery or throbbing heartbeat, frequent urination, hallucinations, headache, hives, hysteria, inability to urinate, increased appetite and weight gain, insomnia, irritability, lack of coordination, light sensitivity, liver problems, low blood pressure, nausea, nervousness, rapid heartbeat, rash and swelling, restlessness, ringing in the ears, sleepiness, stomach pain, stuffy nose, tingling or pins and needles, tremor, vertigo, vision problems (double vision, blurred vision), vomiting, weight gain, wheezing, yellow eyes and skin.

Cyproheptadine is an antihistamine. Cyproheptadine blocks the effects of the naturally occurring chemical histamine in your body.

Cyproheptadine is used to treat sneezing; runny nose; itching, watery eyes; hives; rashes; itching; and other symptoms of allergies and the common cold.

Although not approved by the FDA for this purpose, cyproheptadine has been used to stimulate appetite in underweight patients.

Cyproheptadine may also be used for purposes other than those listed in this medication guide.
What is the most important information I should know about Periactin (cyproheptadine)?
Use caution when driving, operating machinery, or performing other hazardous activities. Cyproheptadine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities. Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while you are taking cyproheptadine.
Who should not take Periactin (cyproheptadine)?
Do not take cyproheptadine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A very dangerous drug interaction could occur, leading to serious side effects.

Before taking this medication, tell your doctor if you have:
*glaucoma or increased pressure in the eye;
*a stomach ulcer;
*an enlarged prostate, bladder problems, or difficulty urinating;
*an overactive thyroid (hyperthyroidism);
*hypertension or any type of heart problems; or
*asthma.

You may not be able to take cyproheptadine, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.
Cyproheptadine is in the FDA pregnancy category B. This means that it is unlikely to harm an unborn baby. Do not take cyproheptadine without first talking to your doctor if you are pregnant. Cyproheptadine passes into breast milk. Infants are especially sensitive to the effects of antihistamines, and serious side effects could occur in a nursing baby. Cyproheptadine is not recommended if you are breast-feeding a baby. Do not take cyproheptadine without first talking to your doctor if you are nursing a baby. If you are over 60 years of age, you may be more likely to experience side effects from cyproheptadine. You may require a lower dose of this medication.

How should I take Periactin (cyproheptadine)?

Take cyproheptadine exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
Take each dose with a full glass of water.

Cyproheptadine can be taken with or without food.

To ensure that you get a correct dose, measure the syrup form of cyproheptadine with a special dose-measuring spoon or cup, not with a regular tablespoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Never take more of this medication than is prescribed for you. The maximum amount of cyproheptadine that you should take in 1 day is 32 mg.
Store cyproheptadine at room temperature away from moisture and heat.
What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication unless otherwise directed by your doctor.

PERIACTIN PRECAUTIONS
PERIACTIN should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: glaucoma (narrow angle), stomach problems (e.g., peptic ulcer, stomach/intestinal obstruction), urinary problems (e.g., enlarged prostate, bladder obstruction). Before using PERIACTIN, tell your doctor or pharmacist your medical history, especially of: asthma, glaucoma, overactive thyroid, heart disease, high blood pressure, seizure disorder, any allergies. This drug may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcoholic beverages. To minimize dizziness, get up slowly when rising from a seated or lying position. Caution is advised when using this drug in the elderly because they may be more sensitive to its side effects. Do not use this drug in infants. Caution is advised when using this drug in children because they may be more sensitive to its side effects, especially excitement and seizures. PERIACTIN should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if PERIACTIN passes into breast milk. Due to the potential risk to the infant, breast-feeding while using this drug is not recommended.

PERIACTIN DRUG INTERACTIONS

Before using PERIACTIN, tell your doctor or pharmacist of all prescription and nonprescription products you may use, especially of: other allergy medications, MAO inhibitors (e.g., furazolidone, linezolid, moclobemide, phenelzine, procarbazine, selegiline, isocarboxazid, tranylcypromine), SSRI anti-depressants (e.g., fluoxetine, citalopram). Before using this medication, tell your doctor or pharmacist of all drugs you may use that cause drowsiness such as: anti-anxiety drugs (e.g., diazepam), other antihistamines that cause drowsiness (e.g., diphenhydramine), anti-seizure drugs (e.g., carbamazepine), medicines for sleep (e.g., sedatives), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., phenothiazines such as chlorpromazine, or tricyclics such as amitriptyline), tranquilizers. Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain drowsiness-causing ingredients. Ask your pharmacist about the safe use of those products. Because this medication may affect allergy testing, you may have to stop its use for several days before the tests are performed. Consult your doctor for further instructions. PERIACTIN can affect the results of certain lab tests (pituitary-adrenal response). Make sure laboratory personnel and your doctors know you use this drug. Do not start or stop any medicine without doctor or pharmacist approval.

PERIACTIN is an antihistamine that provides relief of seasonal and nonseasonal allergy symptoms such as watery and itchy eyes, runny nose and sneezing. It is also used to relieve itching and hives due to some skin conditions.

PERIACTIN CYPROHEPTADINE may also be used for a hormone disorder (Cushing’s syndrome), sexual function problems due to certain drugs, and eating disorders (anorexia nervosa).

HOW TO USE: Take CYPROHEPTADINE Periactin by mouth, usually 2 to 3 times a day; or as directed by your doctor. You may take this drug with food to minimize stomach upset. Dosage is based on your medical condition and response to therapy. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same times each day.

CYPROHEPTADINE PERIACTIN SIDE EFFECTS
CYPROHEPTADINE site effects may include: Drowsiness, dizziness, blurred vision, upset stomach, constipation, increased appetite, weight gain, thickening of mucus in the nose/throat, or dry mouth/throat/nose may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Tell your doctor immediately if any of these serious side effects occur: mental/mood changes, pounding or irregular heartbeat, difficulty urinating.
More highly unlikely but very serious side effects may happen: stomach pain, yellowing eyes and skin, dark urine, unusual tiredness. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, severe dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist.